Medical Conditions Linked to Cognitive Decline in Senior Dogs

Research Study Chiang Mai, Thailand, August 31, 2025 – A 2023 study in Animals reveals that dogs with cognitive dysfunction often present with musculoskeletal and neurological issues, such as pain and sensory decline, underscoring the importance of screening for concurrent medical conditions.

Wrightson et al. (2023) investigated the relationship between canine cognitive dysfunction syndrome (CCDS) and other medical conditions in senior dogs. CCDS is a progressive neurodegenerative disorder comparable to early stages of Alzheimer’s disease in humans, and understanding its interplay with systemic health issues is critical for veterinary care.

The cross-sectional study surveyed 804 senior dogs in the final quarter of their expected lifespan. Using the Canine Cognitive Assessment Scale (CCAS) alongside owner-reported health measures, the researchers identified associations between cognitive decline and signs of disease across four body systems: musculoskeletal–neurological, digestive, metabolic, and dermatological.

Results showed the strongest correlations between cognitive dysfunction and musculoskeletal–neurological problems, particularly pain and sensory decline. Moderate correlations were found with digestive and metabolic disorders, while dermatological conditions showed only a weak relationship. These findings suggest that age-related physical conditions may exacerbate or mask the symptoms of CCDS.

The study emphasizes that veterinarians should screen older dogs for concurrent diseases when diagnosing CCDS, with particular attention to pain management and sensory health. This integrated approach can improve diagnostic accuracy and support better quality of life for aging canine companions.

Source: Wrightson, R., Albertini, M., Pirrone, F., McPeake, K., & Piotti, P. (2023). The Relationship between Signs of Medical Conditions and Cognitive Decline in Senior Dogs. Animals, 13. Authors: R. Wrightson, M. Albertini, F. Pirrone, K. McPeake, P. Piotti. Journal: Animals, Volume 13.

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